gsDesign2: Group Sequential Design with Non-Constant Effect

The goal of 'gsDesign2' is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, 'gsDesign2' offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial flexibility on top of what is in the 'gsDesign' package is intended for selecting boundaries.

Version: 1.1.1
Depends: R (≥ 3.5.0)
Imports: corpcor, data.table, dplyr, gsDesign, gt, methods, mvtnorm, npsurvSS, r2rtf, stats, tibble, tidyr, utils, Rcpp
LinkingTo: Rcpp
Suggests: covr, ggplot2, kableExtra, knitr, rmarkdown, testthat
Published: 2024-02-09
Author: Keaven Anderson [aut], Yilong Zhang [aut], Yujie Zhao [aut, cre], Jianxiao Yang [aut], Nan Xiao [aut], Amin Shirazi [ctb], Ruixue Wang [ctb], Yi Cui [ctb], Ping Yang [ctb], Xin Tong Li [ctb], Chenxiang Li [ctb], Hiroaki Fukuda [ctb], Hongtao Zhang [ctb], Yalin Zhu [ctb], John Blischak [ctb], Merck & Co., Inc., Rahway, NJ, USA and its affiliates [cph]
Maintainer: Yujie Zhao <yujie.zhao at>
License: GPL-3
NeedsCompilation: yes
Materials: README NEWS
CRAN checks: gsDesign2 results


Reference manual: gsDesign2.pdf
Vignettes: Quick start for NPH sample size and power


Package source: gsDesign2_1.1.1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): gsDesign2_1.1.1.tgz, r-oldrel (arm64): gsDesign2_1.1.1.tgz, r-release (x86_64): gsDesign2_1.1.1.tgz
Old sources: gsDesign2 archive

Reverse dependencies:

Reverse suggests: simtrial


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